Mouse Tr1 cells are IL-10+IFN-γ− and suppress T-cell proliferation. Mice were intranasally treated as decribed previously in Figure 3.
Intracellular Type 1 regulatory T (Tr1) cells (IL-10) and Th17 (IL-17) cytokines CD4+ production. Notes: Box and whiskers plot of Tr1-producing ...
Distinct subsets of CD4+ regulatory T cells. Tr1, type 1 regulatory T cells;
Induced T-cell stimulation method: T (anti-CD3, anti-CD28); Treg (anti-IFN-γ, anti-IL-4, TGF-β, retinoic acid, anti-CD3, anti-CD28); Tr1 (Dex, Vit D3, ...
(a) Proliferation of responder CD4+ T cells (Tresp) stimulated in the presence of WT or Entpd1−/− Tr1 cells. The suppression of proliferation is shown ...
Human p41+ Tr1 cell clones suppress expansion of CD4+ T cells. (a) T-cell clones were cocultured together with CFSE-labeled autologous CD4+CD25− T cells ...
Peripheral naive CD4+ T cell precursor cells (THp) can differentiate into three subsets of
... cells carrying the IL-10GFP/Foxp3RFP dual reporter system for live cell analysis. Naive WT and Itk−/− CD4+ T cells were cultured under Tr1 polarizing ...
p41-induced murine Tr1 cells decrease inflammatory T cells in murine aspergillosis. C57BL/6 mice were treated as decribed previously in Figure 3 and ...
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Figure 1: T-cell subsets. Naïve CD4+ T cells are stimulated by antigen presenting cells and the cytokine environment to proliferate into a certain subset.
Tr1 based immunotherapy for autoimmune diseases. CD4+ naive T cells are isolated from patients.
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Development of various T cell subsets including Treg. Conventional CD4+ T cells and Treg originate
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Defect in IL-10 production is independent of the strength of T cell stim.
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CD2 costimulation induced the differentiation of Tr1 T cell clones. Purified human CD4 T cells
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Over the last few years it has become clear that there are more functional subsets of helper T-lymphocytes than just the original Th1, Th2 and Tr1. In ...
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Figure 6: A model for Tr1 cell generation by nasal anti-CD3.Nasal anti-CD3 triggers T cell activation via TCR/CD3 complex. T cell activation in the presence ...
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DEX, dexamethasone; iDC, immature dendritic cells; IFN-a, interferon a; MMF, mycophenolate mofetil; TR1, T regulatory 1; VITD3, ...
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